13

13. Proteínas simplificadas, quimeras, anticuerpos catalíticos.

Bibliografía:

Minimized proteins. BC Cunningham, JA Wells. COSB &: 457-462 (1997)

Design of a monomeric 23-residue polypeptide with defined tertiary structure. Struthers,MD, Cheng RP, Imperiali B. Science (1996) 271: 342-345

Minimizing a binding domain from protein A. Braisted, AC & Wells, JA PNAS (1996) 93: 5688-5692

Minimization of a polypeptide hormone. B Li, JYK Tom, D Oare, R yen, WJ Fairbrother, JA Wells. Science (1994) 270: 1657-1660.

Protein engineering and design for drug delivery. JR Murphy. COSB 6: 541-545 (1996)

Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein. A.M. Vocero-Akbani, N.V. Heyden, N.A. Lissy, L. Ratner, S.F. Dowdy, Nature Medicine (1999) 5:29-33.

Targeting diphteria toxin to growth factor receptors. JR Murphy, JC Van Der Speck. Semin. Cancer Biol. (1995) 6: 259-267. (PEDIDO)

Increased thrombolytic and antithrombotic potency of a fibrin-targeted plasminogen activator in baboons. MS Runge, LA Harker, C Bode, J Ruef, AB Kelly, UM Marzec, E Allen, R Caban, SY Shaw, E Haber, SR Hanson. Circulation (1996) (PEDIDO)

Mechanistic studies of a tyrosine-dependent catalytic antibody. Martin, M.T., Napper, A.D., Schultz, P.G. & Rees, A.R. Biochemistry 30: 9757-9761 (1991)

The scope of antibody catalysis. JR Jacobsen & P. Schultz. COSB 5:818-824 (1995).