Revistas

2024

L.V. Herrera-Marcos, Roberto Martínez-Beamonte, Carmen Arnal, Cristina Barranquero, J.J. Puente-Lanzarote, J.M. Lou-Bonafonte, G. Gonzalo-Romeo, G. Mocciaro, B. Jenkins, J.C. Surra, M.J. Rodríguez-Yoldi, V. Alastrué-Vera, J. Letosa, A. García-Gil, A. Güemes, A. Koulman and J. Osada
Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine non-alcoholic steatohepatitis.
Am. J Physiol-Gastrointestinal and Liver Physiology 2024 (doi: 10.1152/ajpgi.00264.2023)

J. Sánchez-Marco, S.H. Bidooki, R. Abuobeid, C. Barranquero, T. Herrero-Continente, C. Arnal, R. Martínez-Beamonte, R. Lasheras J. C. Surra, M.A. Navarro, M.J. Rodríguez-Yoldi, M. Arruebo, V. Sebastian, J. Osada
Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way.
J Nutr Biochem 2024; 124:109503

2023

S. H. Bidooki., Javier Sánchez-Marco, R. Martínez-Beamonte, T. Herrero-Continente, M.A. Navarro., M. J. Rodríguez-Yoldi and J. Osada
Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 To Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.
Int J Mol Sci 2023; 24: 17131

R. Martínez-Beamonte, J. Sánchez-Marco, M. Gómez, G. Lázaro, M. Barco, T. Herrero-Continente, M. Serrano-Megías, D. Botaya, C. Arnal, C. Barranquero, J. C. Surra, J. Osada and M. A. Navarro
Dietary proteins modulate high density lipoprotein characteristics in a sex-specific way in Apoe-deficient mice.
Nutrition 2023; 116:112211

R. Abuobeid, L.V. Herrera-Marcos, C. Arnal, S.H. Bidooki, J. Sánchez-Marco, R. Lasheras, J.C. Surra, M.J. Rodríguez-Yoldi, R. Martínez-Beamonte and J. Osada
Differentially Expressed Genes in Response to a Squalene-Supplemented Diet Are Accurate Discriminants of Porcine Non-Alcoholic Steatohepatitis.
Int J Mol Sci 2023;.4: 12552

I. Lazaro Lopez, J. Bobi, M. Cofan, G. Kapravelou, A. J. Amor, J. Surra, C. Gomez-Guerrero, E. Ortega, J. Osada, A. P. Dantas A. Sala-Vila
Walnut inclusion in a palm oil-based atherogenic diet promotes traits predicting stable atheroma plaque in Apoe-deficient mice.
Frontiers in Nutr 2023;10: 1079407

L.V. Herrera-Marcos, R. Martínez-Beamonte, Carmen Arnal, C. Barranquero, J.J. Puente-Lanzarote, T. Herrero-Continente, J. M. Lou-Bonafonte, G. Gonzalo-Romeo, G. Mocciaro, B. Jenkins, J.C. Surra, M. J. Rodríguez-Yoldi, J. C. Burillo, R. Lasheras, A. García-Gil, A. Güemes, A. Koulman and J. Osada
Dietary squalene supplementation decreases triglyceride species and modifies phospholipid lipidomic profile in the liver of a porcine model of non-alcoholic steatohepatitis.
J Nutr Biochem 2023, 112: 109207

2022

M. Paesa, C. Ancín-Azpilicueta, G. Velderrain-Rodriguez, O. Martin-Belloso, O. Gualillo, J. Osada, M. J. Rodríguez-Yoldi, G. Mendoza.
Anti-Inflammatory and Chondroprotective Effects Induced by Phenolic Compounds from Onion Waste Extracts in ATDC-5 Chondrogenic Cell Line.
Antioxidants 2022, 11: 2381

R. Martínez-Beamonte, M. Ripalda, T. Herrero-Continente, C. Barranquero, A. Davalos, M. C. López De Las Hazas, I. Alvarez, A.C. Sánchez-Gimeno, J. Raso, C. Arnal, J.C. Surra, J. Osada and M.A. Navarro.
Pulsed electric field increases the extraction yield of extra virgin olive oil without loss of its biological properties.
Frontiers in Nutrition 2022, 9:1065543

J. Quero, J.C. Royo, B. Fodor, M. C. Gimeno, J. Osada, M. J.Rodríguez-Yoldi and E. Cerrada.
Sulfonamide-Derived Dithiocarbamate Gold (I) Complexes Induce the Apoptosis of Colon Cancer Cells by the Activation of Caspase 3 and Redox Imbalance
Biomedicines 2022, 10:1437

J. Quero, L.F. Ballesteros-Giraldo, P. Ferreira-Santos, G. Velderrain-Rodriguez, C.M.R. Rocha, R.N. Pereira, J. Teixeira, O. Martin-Belloso, J. Osada, M.J. Rodriguez-Yoldi.
Unveiling The Antioxidant Therapeutic Functionality Of Sustainable Olive Pomace Active Ingredients.
Antioxidants 2022, 11:828

R. Abuobeid, J. Sánchez-Marco, M. J. Felices, C. Arnal, J. C. Burillo, R. Lasheras, R. Busto, M. A. Lasunción, M. J. , Rodríguez-Yoldi, R. Martínez-Beamonte, J. Osada
Squalene through its post-squalene metabolites is a modulator of hepatic transcriptome in rabbits.
Int J Mol Sci 2022, 23: 4172

M. Paesa, D. Pires-Nogueira, G. Velderrain-Rodriguez, I., Esparza, N. Jiménez-Moreno, G. Mendoza, J. Osada, O. Martin-Belloso, M. , J. Rodriguez-Yoldi, C. Ancín-Azpilicueta.
Valorization of Onion Waste by Obtaining Extracts Rich in Phenolic Compounds and Feasibility of its Therapeutic Use on Colon Cancer.
Antioxidants 2022, 11:733

S. Hesamoddin-Bidooki, T. Alejo, J. Sánchez-Marco, R., Martínez-Beamonte, R. Abuobeid, J. C. Burillo, R. Lasheras, V., Sebastian, M. J. Rodríguez-Yoldi, M. Arruebo, J. Osada.
Squalene Loaded Nanoparticles Effectively Protect Hepatic AML12 Cell Lines against Oxidative and Endoplasmic Reticulum Stress in a TXNDC5-Dependent Way.
Antioxidants 2022, 11:581

J. Sánchez-Marco, R. Martínez-Beamonte, A. De Diego, T., Herrero-Continente, C., Barranquero, C. Arnal, J. Surra, M.A. Navarro, J., Osada
Thioredoxin Domain Containing 5 Suppression Elicits Serum Amyloid A-Containing High-Density Lipoproteins.
Biomedicines 2022, 10:709

L.V. Herrera-Marcos, R. Martínez-Beamonte, M. Macías-Herranz, C. Arnal, C. Barranquero, J.J. Puente-Lanzarote, S. Gascón, T. Herrero-Continente, G. Gonzalo-Romeo, V. Alastrué-Vera, D. Gutiérrez-Blázquez, J. M. Lou-Bonafonte, J.C. Surra, M. J. Rodríguez-Yoldi, A García-Gil, A. Güemes and J Osada
Hepatic Galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.
Scientific Reports 2022, 12, 1024

2021

J. Quero, J. Osada, F. Ruigh, M. C. Gimeno, E. Cerrada and M.J. Rodríguez-Yoldi
Gold (I) Complexes Bearing Alkylated 1,3,5-Triaza-7-Phosphaadamantane Ligands as Thermoresponsive Anticancer Agents in Human Colon Cells.
Biomedicines 2021, 9, 1848

Beamonte, R. Sánchez-Marco, J. Felices, M.J. Barranquero, C. Gascón, S. Arnal, C. Burillo, J. C. Lasheras, R. Busto, R. Lasunción, M. A. Rodríguez-Yoldi M. J. and Osada J.
Dietary squalene modifies plasma lipoproteins and hepatic cholesterol metabolism in rabbits
Food and Function 2021, 12, 8141-8153

Velderrain-Rodríguez, G. R. Quero, J. Osada, J. Martín-Belloso, O. and Rodríguez-Yoldi, M.J.
Phenolic-rich extracts from avocado fruit residues as functional food ingredients with antioxidant and antiproliferative properties.
Biomolecules 2021, 11, 977

I. Mármol, J. Quero, R. Ibarz, P. Ferreira-Santos, J. A. Teixeira, Cristina M.R. Rocha, M. Pérez-Fernández, S. García-Juiz, J. Osada, O. Martín-Belloso and M. J. Rodríguez-Yoldi
Valorization of agro-food by-products and their potential therapeutic applications
Food and Bioproducts Processing, 2021, 128, 247–258

R. Martínez-Beamonte, J. Sánchez-Marco, G. Lázaro, M. Barco, T. Herrero-Continente, M. Serrano-Megías, D. Botaya, C. Arnal, C. Barranquero, J.C. Surra, J. Osada and M.A. Navarro
Dietary avian proteins are comparable to soybean proteins on the atherosclerosis development and fatty liver disease in Apoe-deficient mice
Nutrients, 2021, 13, 1838

J Quero, N Jiménez-Moreno, I Esparza, J Osada, E. Cerrada, C. Ancín-Azpilicueta, M. J. Rodríguez-Yoldi
Grape stem extracts with potential anticancer and antioxidant properties.
Antioxidants, 2021, 10, 243

2020

R. Abuobeid, L. Herrera-Marcos, M. A. Navarro, C. Arnal, R. Martínez-Beamonte, J.C. Surra and J. Osada.
Dietary erythrodiol modifies hepatic transcriptome in a sex and dose-dependent way.
INT. J. MOL. SCI 2020, 21: 7331

C. Gabás-Rivera, E. Jurado-Ruiz, A. Sánchez-Ortiz, E. Romanos, R. Martínez-Beamonte, M. A. Navarro, J.C. Surra, C. Arnal, M.J., Rodríguez-Yoldi, C. Andrés-Lacueva and J. Osada.
Dietary squalene induces Cytochromes Cyp2b10 and Cyp2c55 independently of sex, dose and diet in several mouse models.
MOLECULAR NUTRITION & FOOD RESEARCH 2020, 64: 2000354

R. Garriga, T. Herrero-Continente, M. Palos, V.L. Cebolla, J. Osada, E. Muñoz and M.J. Rodríguez-Yoldi.
Toxicity of carbon nanomaterials and their potential application as drug delivery systems: in vitro studies in Caco-2 and MCF-7 cell lines.
NANOMATERIALS 2020; 10: 1617

S Sancho-Knapik; O Pastor; C Barranquero; L V Herrera-Marcos; N Guillén; C Arnal; S Gascón; M A Navarro; M J Rodríguez-Yoldi; R Busto; M A Lasunción and J Osada.
Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male ApoE-deficient mice consuming a Western diet.
BBA - Molecular and Cell Biology of Lipids 2020, 1865: 158790

J. Lozano-Gerona, A. Oliván-Viguera, P. Delgado-Wicke, V. Singh, B. M. Brown., E. Tapia-Casellas, E. Pueyo, M.S. Valero, A.L. Garcia-Otín, P. Giraldo, E. Abarca-Lachen, J.C. Surra, J. Osada, K.L Hamilton, S. P. Raychaudhuri, M. Marigil, Á. Juarranz, H. Wulff, H.Miura, Y. Gilaberte and R. Koller
Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis.
PLoS One 2020; 15(3):e0222619.

L. Cañes, I. Marti-Pamies, C. Ballester-Servera, A. Herraiz-Martinez, J. Alonso, M. Galán, J Nistal, P. Muniesa, J. Osada, L. Hove-Madsen, C. Rodriguez and J. Martínez-González
Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy.
CLINICAL SCIENCE 2020, 134:359-377

B Martínez-Soriano, A. Güemes, G. Pola, A. Gonzalo, P. Palacios-Gasos, A. C. Navarro, R. Martínez-Beamonte, J. Osada and J. J. García
Effect of melatonin as an antioxidant drug to reverse hepatic steatosis. Experimental model.
CAN J GASTROENTEROL HEPATOL 2020

I Mármol, N Jiménez-Moreno, C Ancín-Azpilicueta, J Osada, E Cerrada and M. J. Rodríguez-Yoldi.
A combination of rosa canina extracts and gold complex favors apoptosis of caco-2 cells by increasing oxidative stress and mitochondrial dysfunction.
ANTIOXIDANTS 2020, 9, 17

L.V. Herrera-Marcos, S. Sancho-Knapik, C. Gabás-Rivera, C. Barranquero, S. Gascón, E. Romanos, R. Martínez-Beamonte, M. A. Navarro, J.C. Surra, C. Arnal, J. A. García-De-Jalón, M. J. Rodríguez-Yoldi, M. Tena-Sempere, C. Sánchez-Ramos, M. Monsalve and J. Osada.
Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27ß mRNA expression in hepatic steatosis of mice fed a western diet.
AM J PHYSIOL ENDOCRINOL AND METABOLISM 2020, 318: 249-261

Martinez-Beamonte, R., T. Sanclemente, J. C. Surra, Osada, J.
Could squalene be an added value to use olive by-products?
J SCIENCE FOOD AGRICULTURE 2020, 100:915-925

2019

J J Gaforio , F Visioli, C Alarcón-de-la-Lastra, O Castañer,M Delgado-Rodríguez, M Fitó, A F Hernández, J R Huertas, M A Martínez-González, J A Menendez , J de la Osada, A Papadaki, T Parrón, J E Pereira, M A Rosillo, C Sánchez-Quesada, L Schwingshackl, E Toledo and A M Tsatsakis.
Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, Jaén (Spain)2018.
NUTRIENTS 2019, 11: 2039

M-C López De Las Hazas, R Martin-Hernández, M C Crespo, J Tomé-Carneiro, L Del Pozo-Acebo, Mb. Ruiz-Roso, J C. Escola-Gil, J Osada, M P. Portillo, J A Martinez, M A. Navarro, L Rubió, M J Motilva, F Visioli and A Dávalos.
Identification and validation of common molecular targets of hydroxytyrosol.
FOOD & FUNCTION 2019, 10:4897-4910.

M. J. Felices, S. Escusol, R. Martinez-Beamonte, S. Gascón, C. Barranquero, C. Sanchez-De-Diego, J. Osada, M. J. Rodríguez-Yoldi.
LPS-squalene interaction on D-galactose intestinal absorption.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY 2019, 75:329-340

Allaoui A, Gascón S, Benomar S, Quero J, Osada J,Nasri M, Rodriguez-Yoldi Mj, Boualga A.
Protein hydrolysates from fenugreek (Trigonella foenum graecum) as nutraceutical molecules in colon cancer.
NUTRIENTS 2019, 11: 724

2018

Allaoui A, Barranquero C, Yahia S, Herrera-Marcos LV, Benomar S, Jridi M, Navarro MA, Rodriguez-Yoldi Mj, Nasri M, Osada J, Boualga A.
Fenugreek proteins and their hydrolysates prevent hypercholesterolemia and enhance the HDL antioxidant properties in rats.
NUTRITION & FOOD SCIENCE 48, 973-989, 2018.

Lou-Bonafonte Jm, Martinez-Beamonte, R., T. Sanclemente, J. C. Surra, Lv Herrera-Marcos, Sanchez-Marco J, Arnal C, Osada, J.
Current insights into the biological action of squalene.
MOL NUTR FOOD RES. 62:1800136, 2018.

Martinez-Beamonte, R., O. Alda, T. Sanclemente, M. J. Felices, S. Escusol, C. Arnal, L.V. Herrera-Marcos, S. Gascón, J. C. Surra, Osada, J., M. J. Rodríguez-Yoldi.
Hepatic subcellular distribution of squalene changes according to the experimental setting.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY 74:531-538, 2018.

Mendiara, I.; Domeno, C.; Nerin, C.; Geurts, A. M.; Osada, J.; Martinez-Beamonte, R.
Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry
J. PHARM. BIOMED. ANAL. 150: 396-405, 2018

Herrera-Marcos, L.V.; Lou-Bonafonte, J.M.; Martinez-Gracia M.V.; Arnal, C.; Navarro, M.A.; Osada, J.
Prenylcysteine oxidase 1, a pro-oxidant enzyme of low density lipoproteins
FRONTIERS IN BIOSCIENCE, Landmark, 23, 1020-1037, January 1, 2018

2017

Herrera-Marcos, L.V.; Lou-Bonafonte, J.M.; Arnal, C.; Navarro, M.A.; Osada, J.
Transcriptomics and the mediterranean diet: a systematic review.
NUTRIENTS 9: 472, 2017

S. Yahia, S. Benomar, F. Dehiba, A. Allaoui, N. Guillen, M.J. Rodriguez-Yoldi, J. Osada; A. Boualga.
Hypocholesterolemic and antioxidant efficiency of chickpea (Cicer arietinum) protein hydrolysates depend on its degree of hydrolysis in cholesterol-fed rat.
NUTRITION & FOOD SCIENCE. 47: 254-269, 2017

J. M. Lou-Bonafonte, C. Gabás-Rivera, M.A. Navarro; J. Osada.
The search for dietary supplements to elevate or activate circulating paraoxonases.
INT J MOL SCI. 18: 416, 2017.

C. Sanz-García, A. Sánchez, C. Contreras-Jurado, C. Cales, C. Barranquero, M. Muñoz, R. Merino, P. Escudero, M.J. Sanz, J. Osada, A. Aranda, S. Alemany.
Map3K8 modulates monocyte state and atherogenesis in apoE-/- mice.
ARTERIOSCLER THROMB VASC BIOL, 37(2):237-246, 2017.

 

2016

Sevelsted Møller, L. Fialla, Ad. Schierwagen R. Biagini M. Liedtke C. Laleman W. Klein S. Reul W. Koch Hansen L. Rabjerg M. Singh V. Surra J. Osada J. Reinehr R. De Muckadell Ob. Köhler R. Trebicka J.
The calcium-activated potassium channel KCA3.1 is an important modulator of hepatic injury.
SCI REP. 6: 28770, 2016.

S. Sancho-Knapik, C. Gabas-Rivera, S. Gascon, E. Romanos, R. Martinez-Beamonte, M.A. Navarro, J.C. Surra, C. Arnal and J. Osada.
Diet and sex hormones regulate hepatic synaptotagmin 1 mRNA in mice.
FRONTIERS IN BIOSCIENCES 8: 129-142, 2016.

 

2015

J. M. Lou-Bonafonte, C. Gabás-Rivera, M.A. Navarro and J. Osada.
PON1 and mediterranean diet.
NUTRIENTS 7: 4068-4092, 2015.

S. Sancho-Knapik, N. Guillén and J. Osada.
Cloning and expression of hepatic synaptotagmin 1 in mouse.
GENE. 562: 236–243, 2015

S. Benomar, A. Boualga, S. Yahia, F. Dehiba, N. Guillén, Mj. Rodriguez-Yoldi and J. Osada.
Differential antioxidative and hypocholesterolemic responses to two fish protein hydrolysates (Sardina pilchardus and Boops boops) in cholesterol-fed rats.
NUTRITION AND FOOD SCIENCE 45: 448-466, 2015

M.J. Rodríguez-Yoldi, S. Gascón, C. Barranquero, A. Garcia_Barrios and J. Osada
Involvement of intracellular signalling in the IL-1ß inhibitory effect on fructose intestinal absorption.
J CELL PHYSIOL. 230: 896-902; 2015

 

2014

E. Horna-Terrón, A. Pradilla-Dieste, C. Sánchez-De-Diego and J. Osada.
TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology.
INT J MOL SC. 15: 15, 23501-23518; 2014.

A. Bassols, C. Costa, P. D. Eckersall, J. Osada, J. Sabrià and J. Tibau.
The pig as an animal model for human pathologies: a proteomics perspective.
PROTEOMICS CLINICAL APPLICATIONS. 8:715-31, 2014

C. Gabás-Rivera, C. Barranquero, R. Martínez-Beamonte, M.A. Navarro, J.C. Surra and J. Osada.
Dietary squalene increases high density lipoprotein-cholesterol and paraoxonase 1 and decreases oxidative stress in mice.
PLOS ONE, 9:e104224, 2014

Orriols M, Guadall A, Galán M, Martí-Pàmies I, Varona S, Rodríguez-Calvo R, Briones AM, Navarro MA, De Diego A, Osada J, Martínez-González J and Rodríguez C.
Lysyl oxidase (LOX) in vascular remodelling. Insight from a new animal model.
THROMB HAEMOST. 112:812-24. 2014

S. Olivan, R. Martínez-Beamonte, A.C. Calvo, J.C. Surra, R. Manzano, C. Arnal, Osta, R. and J. Osada.
Extra virgin olive oil intake delays the development of amyotrophic lateral sclerosis associated with reduced reticulum stress and autophagy in muscle of sod1g93a mice.
J NUTR BIOCHEM. 25:885-92. 2014

Lezcano Ej, Iñigo P, Larraga Am, Barranquero C, Gimenez I, and Osada J.
Caloric restriction or telmisartan control dyslipidemia and nephropathy in obese diabetic Zücker rats.
DIABETOL METAB SYNDR. 2014 Jan 27;6(1)

2013

Osada, J.
The use of transcriptomics to unveil the role of nutrients in mammalian liver.
ISRN NUTRITION. 2013. Article ID 403792.

C. Gabás-Rivera, R. Martínez-Beamonte, J.L. Ríos, M.A. Navarro, J.C. Surra, C. Arnal, M.J. Rodríguez-Yoldi and J. Osada
Dietary oleanolic acid mediates circadian clock gene expression in liver independently of diet and animal model but requires apolipoprotein A1.
J NUTR BIOCHEM. 2013; 24: 2100-9

C. Viñuales, S. Gascón, C. Barranquero, J. Osada and Mª J. Rodríguez-Yoldi
Interleukin-1beta reduces galactose transport in intestinal epithelial cells in a NF-kB and protein kinase C-dependent manner.
VET IMMUNOL AND IMMUNOPATHOL. 2013; 155:171-81

Julve J, Escolà-Gil Jc, Rodríguez-Millán E, Martin-Campos Jm, Jauhiannen M, Quesada H, Renteria-Obregón Im, Osada J, Sanchez-Quesada Jl, Blanco-Vaca F.
Methionine-induced hyperhomocysteinemia impairs the antioxidant ability of high-density lipoproteins without reducing in vivo macrophage-specific reverse cholesterol transport.

MOL NUTR FOOD RES. 2013; 57:1814–1824

Rodríguez-Calvo R, Guadall A, Calvayrac O, Navarro M. A., Alonso J, Beatriz Ferrán, De Diego A, Muniesa P, J Osada, C Rodríguez, Martínez-González, J.
Over-expression of neuron-derived orphan receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury.
HUMAN MOL GENETICS 2013; 22:1949-59.

Martínez-Beamonte R, Lou-Bonafonte, J.M., Martínez-Gracia, M.V., and Osada J.
Sphingomyelin in high-density lipoproteins: structural role and biological function.

INT J MOL SCI. 2013; 14: 7716-7741

Martínez-Beamonte R, Navarro Ma, Acin S, Guillén N, Barranquero C, Arnal C, Surra J, Osada J.
Postprandial changes in high density lipoproteins in rats subjected to gavage administration of virgin olive oil.
PLOS ONE. 2013. 10.1371/journal.pone.0055231

J C. Surra, C. Barranquero, M. P. Torcal, I.Orman, J. C. Segovia,.N. Guillén, M. A. Navarro, C. Arnal and Osada J.
In comparison with palm oil, dietary nut supplementation delays progression of atherosclerotic lesions in female apoE-deficient mice.
BR. J NUTR. 2013; 109: 203-209

2012

Gonzalo Ma, Martínez-Beamonte R, Palacios P, Marín J, Castiella T, Surra J, Burdío F, Sousa R, Güemes A, Osada J, García-Gil A.
Analysis of tissue bioimpedance as a measurement of liver steatosis: experimental model in large animals.
TRANSPLANT PROC. 2012; 44:1579-83

A. Ramírez-Torres, S. Barceló-Batllori, R. Martínez-Beamonte, M. A. Navarro, J. C. Surra, C. Arnal, N. Guillén, S. Acín and Osada J.
Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis.
J PROTEOMICS. 77: 27 – 39. 2012.

C. Viñuales, S. Gascón, C. Barranquero, J. Osada and Mª J. Rodríguez-Yoldi.
Inhibitory effect of IL-1ß on galactose intestinal absorption in rabbits.
CELL PHYSIOL AND BIOCHEM. 30:173-186. 2012

M. Nuño-Ayala, N. Guillen, C. Arnal, J.M. Lou-Bonafonte, A. De Martino, J.-A. García-De-Jalón, S. Gascón, L. Osaba, J.Osada and M. A. Navarro.
Cystathionine ß-synthase deficiency causes infertility by impairing decidualization and gene expression networks in uterus implantation sites.
PHYSIOL GENOMICS. 44:702-16. 2012

L. Fraile, E. Crisci, L. Córdoba, M. A. Navarro, J. Osada and M. Montoya.
Immunomodulatory properties of phytosterols in pigs.
INTERNATIONAL IMMUNOPHARMACOLOGY. 13:316-321. 2012

J.M. Lou-Bonafonte, M. A. Navarro, C. Arnal, and Osada J.
Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development.
MOL NUTR FOOD RES. 56:1043-57. 2012

Lou-Bonafonte, J.M., Fitó M, Covas Mi, Farràs M, and Osada J.
HDL-related mechanisms of olive oil protection in cardiovascular disease.
CURRENT VASC PHARMACOL.10: 392-409. 2012

A. Ramírez-Torres, S. Barceló-Batllori, E. Fernández-Vizarra, M. A. Navarro, C. Arnal, N. Guillén, S. Acín and Osada J.
Proteomics and gene expression analyses of mitochondria from squalene-treated apoE-deficient mice identify short-chain specific acyl-CoA dehydrogenase changes associated with fatty liver amelioration.
J PROTEOMICS 75:2563-2575. 2012

2011

Lou-Bonafonte, J.M., Arnal, C. and Osada J.
New genes involved in hepatic steatosis.
CURRENT OPINION IN LIPIDOLOGY 22:159-64. 2011.

Martinez-Beamonte, R., Navarro, M. A., Larraga, A., Strunk, M., Barranquero, C., Acin, S., Guzmán, M.A., Iñigo P. and Osada J.
Selection of reference genes for gene expression studies in rats.
J BIOTECHNOL 151:325-34. 2011. http:// 10.1016/j.jbiotec.2010.12.017

Martinez-Beamonte, R., Navarro, M. A., Guillén, N., Acin, S., Arnal, C., Guzmán, M.A. and Osada J.
Postprandial transcriptome associated with virgin olive oil intake in rat liver.
FRONTIERS IN BIOSCIENCES 3:11-21. 2011

2010

García-Barrios, A, Guillén, N, Gascón, S, Osada, J, Vázquez, CM, Miguel-Carrasco, JL and Rodríguez-Yoldi MJ.
Nitric oxide involved in the IL-1beta-induced inhibition of fructose intestinal transport.
J CELL BIOCHEM. 111:1321–1329. 2010

Nuño, M., Guillén, N., Navarro, M. A., Lou-Bonafonte, J.M., Arnal, C., Gascón, S., Barranquero, C., Godino, J., Royo, M., Sarría, A.J., Guzmán, M.A., Hernandez, E., Bregante, M. A., García-Gimeno, M. A. and Osada J.
Cysteinemia, rather than homocysteinemia, is associated with plasma apolipoprotein A-I levels in hyperhomocysteinemia.
ATHEROSCLEROSIS 212:268-273, 2010

Surra, J.C., Guillén, N., Arbonés-Mainar, J. M., Barranquero, C., Navarro, M. A., Arnal, C., Orman, I., Segovia, J.C. and Osada, J.
Sex as a profound modifier of atherosclerotic lesion development in apolipoprotein E-deficient mice with different genetic backgrounds.
J ATHEROSCLER AND THROMB 17: 712-721, 2010

López-Miranda J, Pérez-Jiménez F, Ros E, De Caterina R, Badimón L, Covas MI, Escrich E, Ordovás JM, Soriguer F, Abiá R, Alarcón de la Lastra C, Battino M, Corella D, Chamorro-Quirós J, Delgado-Lista J, Giugliano D, Esposito K, Estruch R, Fernandez-Real JM, Gaforio JJ, La Vecchia C, Lairon D, López-Segura F, Mata P, Menéndez JA, Muriana FJ, Osada J, Panagiotakos DB, Paniagua JA, Pérez-Martinez P, Peinado MA, Pineda-Priego M, Poulsen HE, Quiles JL, Ramírez-Tortosa MC, Ruano J, Serra-Majem L, Solá R, Solanas M, Solfrizzi V, R de la Torre-Fornell, Trichopoulou A, Uceda M, Villalba-Montoro JM, Villar-Ortiz JR, Visioli F, Yiannakouris N.
Olive oil and health: summary of the ii international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008.
NUTR METAB CARDIOVASC DIS. 20:284-94, 2010

Surra, J.C., Guillén, N., Barranquero, C., Arbonés-Mainar, J. M., Navarro, M. A., Gascón, S., Arnal, C. Godino, J., Guzmán, M. A., Díaz-Gil, J.J. and Osada J.
Sex-dependent effect of liver growth factor on atherosclerotic lesions and fatty liver disease in apolipoprotein E knockout mice.
HISTOL AND HISTOPATHOL 25:609-18, 2010

Alemany, R., Navarro, M. A., Vögler, O., Perona, J. S., Osada J. and Ruiz-Gutiérrez, V.
Olive oils modulate fatty acid content and signaling protein expression in apolipoprotein E knockout mice brain.
LIPIDS 45:53-61, 2010

Navarro,M. A., Badimon,L., Rodriguez, C., Arnal,C., Noone,E., Roche,H., Osada J. and Martínez-González, J.
Trans-10,cis-12-CLA dysregulate lipid and glucose metabolism and induce hepatic NR4A receptors.
FRONTIERS IN BIOSCIENCE 2: 87-97, 2010

2009

Guillén, N., Navarro, M. A., Arnal, C. Noone, E., Arbonés-Mainar, J. M., Acín, S., Surra, J.C., Muniesa, P., Roche, H. and Osada J.
Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver.
PHYSIOL GENOMICS 37: 187-198, 2009

Carnicer, R. Guillén, N., Arbonés-Mainar, J. M., Navarro, M. A. Guzmán, M.A. Barranquero, C., Arnal, C. Gascón, Acín,S., Mourelle, M. and Osada J.
Nitric oxide-releasing agent, La419, reduces atherogenesis in apolipoprotein E deficient mice.
NAUNYN-SCHMIEDEBERG ARCHIVES OF PHARMACOLOGY 379:489 – 500. 2009

Guillen, N., Acín, S., Navarro, M.A., Martínez-Gracia, M.V., Surra, J.C., Arnal, C., Lou-Bonafonte, J.M., Muniesa, P. and Osada, J.
The knowledge of biological action of extra virgin olive oil by using the mouse lacking apolipoprotein E.
REV ESP CARDIOL. 62: 294-304. 2009 Versión en español

Guillen, N. Acín, S. Surra, J.C. Arnal, C. Godino, J. García-Granados, A. Muniesa, P. Ruiz-Gutiérrez, V. and Osada, J. Apolipoprotein e determines the hepatic transcriptional profile of dietary maslinic acid in mice.
J. NUTR. BIOCHEM. 20: 882-893, 2009


2008

Amador, P., Marca, M. C., García-Herrera, J., Lostao, M.P., Guillén, N., Osada J. and Rodríguez-Yoldi, M. J.
Lipopolysaccharide induces inhibition of galactose intestinal transport in rabbits in vitro.
CELL PHYSIOL BIOCHEM 22: 715-72, 2008

Carnicer, R., Guzman; M.A., Acín S. Surra, J. C., Navarro, M. A. Arnal, C. Arbonés-Mainar, J. M., Morales, R y Osada J.
Genetic background in apolipoprotein A-I and cystathionine ß-synthase deficiency.
FRONTIERS IN BIOSCIENCE 13: 5155-5162, 2008

Carnicer, R. Navarro, M. A. Guillén, N. Arbonés-Mainar, J. M. Surra, J. C Acín S. y Osada J.
Simvastatin reverses the hypertension of heterozygous mice lacking cystathionine ß-synthase and apolipoprotein A-I.
NAUNYN-SCHMIEDEBERG ARCHIVES OF PHARMACOLOGY 377: 35-43, 2008

N. Guillén, S. Acín, M. A. Navarro, J. S. Perona, J. M. Arbonés-Mainar, C. Arnal, A.J. Sarría, J. C. Surra, R. Carnicer, I. Orman, J. C. Segovia, V. Ruiz-Gutiérrez y J. Osada.
Squalene in a sex-dependent manner modulates atherosclerotic lesion which correlates with hepatic fat content in apoE- knockout male mice.
ATHEROSCLEROSIS 197: 72-83, 2008

García-Herrera, J.; Marca, M.C.; Brot-Laroche, E.; Guillen, N.; Acín, S.; Navarro, M. A.; Osada, J.; Rodríguez-Yoldi, M.J.
Proteinkinases, TNF-alpha and proteasome contribute in the inhibition of fructose intestinal transport by sepsis "in vivo”.
AMERICAN JOURNAL PHYSIOLOGY: GI AND LIVER PHYSIOLOGY 294: G155-164, 2008


2007

J.M. Arbonés-Mainar, K Ross, G Rucklidge, M. Reid, G. Duncan, JR Arthur, G. Horgan, M.A. Navarro, R. Carnicer, C. Arnal, J. Osada y B De Roos.  
Extra virgin olive oils increase hepatic fat accumulation and hepatic antioxidant protein levels in apoE-/- mice.
J PROTEOME RESEARCH 6: 4041-4054, 2007  

J. M. Arbonés-Mainar, M. A. Navarro, R. Carnicer, N. Guillén, J.C. Surra, S. Acín, M. A. Guzmán, A. J. Sarría, C. Arnal, M.P. Aguilera, A. Jiménez, G. Beltrán, M. Uceda y J. Osada.  
Accelerated atherosclerosis in apolipoprotein E-deficient mice fed Western diets containing palm oil compared with extra virgin olive oils: A role for small, dense high-density lipoproteins.
ATHEROSCLEROSIS 194: 372-382, 2007 

R. Carnicer, M.A. Navarro, J.M. Arbonés-Mainar, C. Arnal, J.C. Surra, S. Acín, A.J. Sarría, F. Blanco-Vaca, N. Maeda y J. Osada.
Genetically-based hypertension generated through interaction of mild hypoalphalipoproteinemia and mild hyperhomocysteinemia.
J HYPERTENSION 25:1597–1607, 2007  

P. Amador, J. García-Herrera, M.C. Marca, J. De La Osada, S. Acín, M.A. Navarro, M.T. Salvador, P. Lostao y M. J. Rodríguez-Yoldi.
Intestinal D-galactose transport in an endotoxaemia model in the rabbit.
JOURNAL MEMBRANE BIOLOGY 215:125-133, 2007

R. Carnicer, M. A. Navarro, J. M. Arbonés-Mainar, S. Acín, M. A. Guzmán, J. C. Surra, C. Arnal, M. De Las Heras, F. Blanco-Vaca y J. Osada.
Folic acid supplementation delays atherosclerotic lesion development in apoE-deficient mice.
LIFE SCIENCES. 80:638-643, 2007

Guillén, N., Navarro, M. A., Surra, J. C., Arnal, C. Fernández-Juan, M. Cebrián-Pérez J. A. y J. Osada.
Cloning, characterization, expression and comparative analysis of pig Golgi membrane sphingomyelin synthase 1.
GENE 388: 117-24, 2007

Acín, S., Navarro M.A., Perona, J.S., Surra, J. C., Guillén, N., Arnal, C., Sarría, A. J., Arbonés-Mainar, J. M., Carnicer, R., Ruiz-Gutiérrez, V. y Osada J.
Microarray analysis of hepatic genes differentially expressed in the presence of the unsaponifiable fraction of olive oil in apolipoprotein E-deficient mice.
BR. J NUTR. 97:628-638, 2007  

P. Amador, J. García-Herrera , M.C. Marca, J. De La Osada, S. Acín, M.A. Navarro, M.T. Salvador, P. Lostao y M. J. Rodríguez-Yoldi.
Inhibitory effect of TNF-a on the intestinal absorption of galactose.
J. CELL. BIOCHEM 101: 99-111, 2007  

Acín, S., Navarro M.A., Perona, J.S., Arbonés-Mainar, J. M. Surra, J. C. Guzman, M.A. Carnicer, R. Arnal, C., Orman, I. Segovia, J. C. De La Torre, R. Covas, M.-I. Osada J. y Ruiz-Gutiérrez V.
Olive oil preparation determines the atherosclerotic protection in apolipoprotein E knockout mice.
J. NUTR. BIOCHEM. 18:418-424, 2007  

Cabello-Moruno R, Perona JS, Osada J, Garcia M y Ruiz-Gutierrez V.
Modifications in postprandial triglyceride-rich lipoprotein composition and size after the intake of pomace olive oil.
J. AM. COL. NUTR. 26: 24-31, 2007  


2006

M. A. Guzmán, M. A. Navarro, R. Carnicer, A. J. Sarría, S. Acín, C. Arnal, P. Muniesa, J. C. Surra, J. M. Arbonés-Mainar, N. Maeda y J. Osada.
Cystathionine b-synthase is essential for female reproductive function.
HUMAN MOL GENETICS, 15: 3168-3176, 2006  

M.I. Covas, V. Ruiz-Gutierrez, R. De La Torre, A. Kafatos, R. M. Lamuela-Raventos, J. Osada, R.W. Owen y F. Visioli.
Minor components of olive oil: evidence to date of health benefits in humans.
NUTRITION REVIEWS 64:S20-S30, 2006

Acín, S. Navarro M.A., Arbonés-Mainar, J. M. Guillén, N.. Sarría A. J, Carnicer, R. Surra, J. C. Orman, I. Segovia, J. C. de la Torre, R. Covas, M.-I. Fernández-Bolaños, J. Ruiz-Gutiérrez V. y Osada J.
Hydroxytyrosol administration enhances atherosclerotic lesion development in apo E deficient mice.
J. BIOCHEM. 140: 383-91, 2006

Arbonés-Mainar, J. M., Navarro, M.A., Guzmán, M. A., Arnal, C., Surra, J. C., Acín, S., Carnicer, R., Osada,J. and Roche, H.M.
Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice.
ATHEROSCLEROSIS, 189: 318-327; 2006  

Arbonés-Mainar, J. M., Navarro, M.A., Acín, S., Guzmán, M. A., Arnal, C., Surra, J. C., Carnicer, R., Roche, H.M. and Osada,J.
Trans-10, cis-12- and cis-9, trans-11-Conjugated Linoleic Acid Isomers Selectively Modify HDL-Apolipoprotein Composition in Apolipoprotein E Knockout Mice.

J NUTRITION 136: 353-359, 2006   cover image: see article Arbonés-Mainar, J.M.
Sarría , A. J. Surra , J. C. Acín, S. Carnicer, R. Navarro, M. A. Arbonés-Mainar, J. M. Guillen, N. Martínez-Gracia, M. V. Arnal C. and Osada J.  
Understanding the role of dietary components on atherosclerosis using genetic engineered mouse models.  
FRONTIERS IN BIOSCIENCE 11: 955-967, 2006

2005

Alvarez De Cienfuegos G, Badimon L, Ordovás J, Osada J et al.
International conference on the healthy effect of virgin olive oil.  
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 35: 421-424, 2005  

De Roos, B., Rucklidge, G., Reid, M., Pickard, K., Duncan, G., Navarro, M.A., Arbones-Mainar, J.M., Guzman-Garcia, M.A., Osada, J., Browne, J. Loscher, C.E. Roche H.M.  
Divergent mechanisms of cis9,trans11- and trans10,cis12- conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach.
FASEB J 19:1746-1748, 2005              

Navarro, M. A. Carpintero, R. Acín, S. Arbonés- Mainar, J. M. Calleja, L. Carnicer, R. Surra, J. C. Guzmán-García, M. A. N. González-Ramón, M. Iturralde, F. Lampreave, A. Piñeiro, Osada, J.
Immune-regulation of the apolipoprotein A-I/C-III/A-V gene cluster in experimental inflammation.
CYTOKINE 31: 52-63, 2005  

Acín, S., Navarro, M.A., Carnicer, R., Arbonés-Mainar, J. M. Guzmán, M. A., Arnal, C., Beltrán, G. Uceda, M., Maeda N., Osada, J.
Dietary cholesterol suppresses the ability of olive oil to delay the development of atherosclerotic lesions in apolipoprotein E knockout mice.
ATHEROSCLEROSIS 182:17-28
, 2005  

2004

Navarro M. A., Acín S., Carnicer R., Guzmán-García M. A., Arbonés-Mainar J. M., Surra J.C., Cebrián J. A., Arnal C. Isabel B., López-Bote C. J., Osada, J.
Response of apolipoprotein a-iv in pigs to long-term increased dietary oil intake, and to the degree of unsaturation of the fatty acids involved.
BR. J NUTR. 92: 763-769, 2004  

Navarro M. A., Acín S., Iturralde M., Calleja L., Carnicer R., Guzmán-García M. A., González-Ramón N., Mata P., Isabel B., López-Bote C. J., Lampreave F., Piñeiro A., Osada, J.
Cloning, characterization and comparative analysis of pig plasma apolipoprotein A-IV.
GENE 325:157-164, 2004  

Garcia-Herrera J., Navarro M.A., Marca M.C., Osada, J, Rodriguez-Yoldi M.J.
The effect of tumor necrosis factor on fructose intestinal transport in rabbits.
CYTOKINE 25:21-30, 2004  


Anteriores

Calleja, L., Trallero, M.C., Carrizosa, C., Méndez, M.T., Palacios-Alaiz, E. and Osada, J.
Effects of dietary fat amount and saturation on the regulation of hepatic mRNA and plasma apolipoprotein A-I in rats.
ATHEROSCLEROSIS. 152: 69-78, 2000  

Osada, J., Joven, J., Maeda, N.  
The value of apolipoprotein e knockout mice for studying the efffects of dietary fat and cholesterol on atherogenesis.
CURRENT OPINION IN LIPIDOLOGY 11: 25-29, 2000  

Calleja, L., París, M.A., Paul. A., Vilella, E., Joven, J., Jiménez, A., Beltrán, G., Uceda, M., Maeda, N., Osada, J.
Low cholesterol and high fat diets reduce atherosclerotic lesion development in apolipoprotein e knockout mice.
ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 2368-2375, 1999